Long before European settlers arrived in the Conococheague Valley, the ridges and hollows of what is now Franklin County, Pennsylvania were home to the Massawomeck and Lenape peoples — part of the broader Iroquois world that shaped this landscape for centuries. The Tuscarora Mountains, which form the western wall of Blair's Valley, take their name from the Tuscarora Nation, an Iroquoian-speaking people who migrated north from the Carolinas around 1713 after devastating warfare, eventually settling in New York as the sixth nation of the Haudenosaunee Confederacy.
The valley itself served as a natural corridor — a passage between the Great Appalachian Valley to the east and the mountains to the west. Its flat bottomland along Blairs Valley Road, sheltered by ridges on both sides, made it an ideal hunting ground and seasonal camp. These same geographic qualities would later make it attractive to the Scots-Irish and German settlers who arrived in the 1730s and 1740s.
"The land now called Blair's Valley was once occupied by the Delaware, but ownership was claimed by the Iroquois — a vast hunting ground and corridor of commerce."